Stem cell based glioblastoma gene therapy
نویسندگان
چکیده
منابع مشابه
Stem cell based glioblastoma gene therapy Minireview**
There is no curative therapy for glioblastoma multiforme (GBM) thus far. Combined therapies including surgery, followed by concomitant irradiation and chemotherapy with the DNA alkylating agent temozolomide (TMZ), slightly improves patients’ survival but the prognosis remains poor. The fatal nature of glioblastoma is caused by tumor-initiating glioblastoma cells. The tumor tropic ability of adu...
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Glioblastoma multiforme (GBM), designated as World Health Organization (WHO) grade IV astrocytoma, is a lethal and therapy-resistant brain cancer comprised of several tumor cell subpopulations, including GBM stem cells (GSCs) which are believed to contribute to tumor recurrence following initial response to therapies. Emerging evidence demonstrates that GBM tumors are initiated from GSCs. The d...
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Cell therapy is a modern approach in the treatment of most of the diseases which uses stem cells and it has been recently developed rapidly. Cell therapy has shown satisfactory results in this way. Our country, Iran, has played an important role in the development of this new method and the results of stem cell treatment used for the most of the diseases were successful. The results have led to...
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Gene therapy applications that target hematopoietic stem cells (HSCs) offer great potential for the treatment of hematologic disease. Despite this promise, clinical success has been limited by poor rates of gene transfer, poor engraftment of modified cells, and poor levels of gene expression. We describe here the basic approach used for HSC gene therapy, briefly review some of the seminal clini...
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Glioblastoma (GBM) is the most common and deadliest primary tumor in adults, with current treatments having limited specific and efficient delivery of therapeutic drugs to tumor sites or cells. Therefore, the development of alternative treatment options is urgently needed. Stem cells are considered as ideal cellular vehicles for gene therapy against glioblastoma. In this paper, we reviewed the ...
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ژورنال
عنوان ژورنال: Neoplasma
سال: 2012
ISSN: 1338-4317
DOI: 10.4149/neo_2012_95